Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease
Timon Merk, Victoria Peterson, Witold J Lipski, Benjamin Blankertz, Robert S Turner, Ningfei Li, Andreas Horn, Robert Mark Richardson, Wolf-Julian Neumann (2022) Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease eLife 11:e75126
Interventional & Cognitive Neuromodulation
led by Wolf-Julian Neumann (Dr. med.)
part of the Movement Disorders Unit,
Department of Neurology,
Charité - Berlin, Germany
In our lab, we combine multimodal research methods including invasive human neurophysiology (local field potentials and electrocorticography), non-invasive neurophysiology (magneto-/electroencephalography), and structural and functional neuroimaging with access to 3T MRI in the department of neuroradiology.
Our projects explore how neural activity is synchronized across multiple nodes of the motor circuit.
We investigate how such activity is implicated in neurological disorders and how these findings can be translated into next-generation therapeutic neuromodulation approaches.
Key research points
Functional relevance of oscillatory activity on cognitive and motor control
based and real-time prediction of human behaviour from invasive recordings
Mechanisms of synaptic plasticity in the pathophysiology of the disease
Developing solutions for multimodal clinical neuroscience research data